proin vs incurin

Paste as plain text instead, Madison, NJ: Intervet Inc.; 2011. Accessed October 2020. Our mission is to provide pet parents just like you with the most up-to-date expert information and resources you need to make better, more informed decisions that support the health and happiness of your companion animals. The information is NOT to be used for diagnosis or treatment of your pet. 13. The author believes that cystopexy is contraindicated in these cases since it may result in detrusor instability, a further cause of urinary incontinence! However due to the ease of dosing, high efficacy and safety of PROIN ER, it would be appropriate to prescribe PROIN ER first line for at least 30 days to evaluate whether another option should be explored. Prior to its discontinuation in humans, combined therapy with phenylpropanolamine and estrogen derivatives was found to be synergistic, with increases in maximum urethral closure and reductions in leakage episodes.19-21 One recent study in healthy beagles without USMI showed no improvement in maximum urethral pressure or closure pressure when phenylpropanolamine was added to estriol.22 However, as there are likely differences in the functional urodynamics of unaffected animals and dogs with USMI, additional studies are warranted. PROIN chewable tablets. She looked at me, whined and then I felt wet. New comments cannot be posted and votes cannot be cast. Arnold S. Urinary incontinence in castrated bitches. Thank you. New comments cannot be posted and votes cannot be cast . Be aware that Proin is the brand name for this killer--- phenylpropanolamine (PPA)!! Medical therapy of urinary incontinence in ovariectomised bitches: a comparison of the effectiveness of diethylstilboestrol and pseudoephedrine. WebThere have never been head-to-head trials with Diethylstilbestrol (DES) or Incurin. This is a sub for professional veterinary advice, and as such we follow strict rules for participating. 5. WebProin vs. Proin ER Comparison | PetMeds FREE Standard Shipping When You Spend $49+ EXTRA 40% OFF Use code NEW40 in cart (up to $40 discount) 2% Back on all Proin for Dogs: A Simple Solution for Urinary Incontinence, Yes, you can give your dog Proin for control of urinary incontinence. Res. Claudia & Greyhound Gang100% Helps Hounds. Flea Pills for Dogs: The Ultimate Guide Every Pet Owner Must Read, Cephalexin For Dogs: Recommended Dosage, Side Effects, and More, Enalapril for Dogs: Side Effects, Dosage, and More, Colloidal Silver For Dogs: A Natural Antibiotic for Sick Dogs. Some limitations and restrictions may apply. prnpharmacal.com/products/urinary-health/proin-chewable-tablets. is the only veterinary Food and Drug Administration (FDA)-approved phenylpropanolamine hydrochloride medication marketed in the United States to treat urinary incontinence due to hypotonicity of the urethral sphincter. 125, 478-480. Res. The active ingredient Phenylpropanolamine is an adrenergic agent that activates the adrenal receptors, similar mechanism of action like epinephrine and norepinephrine. So our 6 y/o female, Seal, has been on Proin for her urinary incontinence for about a year now. The recommended labeled dose for Proin is 2 mg/kg PO q12h, to be dosed to the nearest half-tablet. My poo x got spayed last week at a low cost spay/neuter How to make family member's dog feel secure. Common side effects of Proin in dogs include diarrhea, vomiting, loss of appetite, weight loss, irritability, restlessness, agitation, vocalization, difficulty urinating, increased thirst (polydipsia), increased water intake, and lethargy. *If your pet is in need of urgent or emergency care, contact your pet's veterinarian immediately. Dogs can stay on Proin for over 180 days without developing serious issues. However, taking body size into consideration, bitches with sphincter mechanism incompetence tend to have shorter urethras than continent animals. Affected spayed bitches may respond well to oestrogen therapy but in some animals the response ceases eventually, despite increasing the dosage of oestrogens, possibly due to desensitisation of oestrogen receptors. The information presented is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. Some animals show no response. The introduction of urethral pressure profilometry as an investigative aid in the bitch has allowed confirmation of the belief that poor urethral tone is implicated in urinary incontinence due to sphincter mechanism incompetence. Our vet does not have it. In theory, sympathomimetic or parasympatholytic agents should improve continence control by increasing urethral tone or reducing intravesical pressure respectively but the results of clinical trials are variable and possible long-term adverse systemic effects have not been evaluated. Incurin (estriol) Tablets for Dogs [Freedom of Information Summary]. As in the bitch, the condition can occur as either a congenital or acquired condition. It does have different side effects. Were sorry, but our website doesnt work properly without JavaScript enabled. She gradually started leaking more over the last year. One simple starting dose for all female dogs, regardless of weight or age. One study showed that sympathomimetic drugs (pseudoephedrine) were more effective at controlling urinary incontinence than DES (82.4% versus 64.5%).16 However, more recent studies of estriol have shown reported efficacies between 83% and 89.8%, similar to that of phenylpropanolamine.17,18. Your IP: Medical therapy of urinary incontinence in ovariectomised bitches: a comparison of the effectiveness of diethylstilboestrol and pseudoephedrine. Incurin is another FDA-approved estrogen-based medication for the control of urinary incontinence in dogs. in dogs include diarrhea, vomiting, loss of appetite, weight loss, irritability, restlessness, agitation, vocalization, difficulty urinating, increased thirst (polydipsia), increased water intake, and lethargy. Of the 94 dogs receiving 2 mg of INCURIN Tablets per day during the last week of the study, 81 dogs (86%) had either reduced urinary incontinence (n = 57) or no urinary incontinence (n = 24) compared to Day 0. U.S. Food and Drug Administration. Two weeks and no adverse side effects. The agonistic and antagonistic actions of estriol. Biopharm Drug Dispos. That def makes me feel better! Reddit and its partners use cookies and similar technologies to provide you with a better experience. I have seen online posts that both can be used at the same time as they work/target a dogs body differently but I cant find a vet that will do both. I am a bot, and this action was performed automatically. 1988;32(2):273-280. U.S. Food and Drug Administration. October 2020. Therapy with concurrent NSAIDs, reserpine, or tricyclic antidepressants may increase the risk of hypertension. Display as a link instead, The proin helped reduce the leaking but never fully stopped it. In addition to hypertension, dogs in the 3 and 5 manufacturer safety dosing groups were found to have significant elevations in platelet counts, alanine aminotransferase (ALT), and lactate dehydrogenase.4 Similarly, short-term dosing of phenylpropanolamine at 10 the recommended dose for 21 days resulted in hypertension, bradycardia, vomiting, leukocytosis, thrombocytosis, and elevations in ALT. The 2 times this happened, she was laying in bed next to me. Cancel or update at anytime. Neither the Company nor any of its employees or consultants make any warranties, expressed or implied, or representations about the accuracy or completeness of the content or the content of any site or external sites. Heartgard for Dogs: How it Works and What it Does? 21. Similar results have been obtained with urethropexy (White 2001). ADVERSE REACTIONS: Mild, oestrogenic effects such as swollen vulva, swollen teats and/or attractiveness for males have been observed at the high dose of 2 mg. I also think she is less agitated and resting better. No medical reasoning behind the decision other than dogs cant be on both.. Myocardial hypertrophy associated with long-term phenylpropanolamine use in a dog. Vet. Is anyone familiar with that one? A Guide to Aspirin for Dogs Dosage & More! They did their tests and came back with the same conclusion. 18. Proin (PRN Pharmacal, prnpharmacal.com) is the only veterinary Food and Drug Administration (FDA)-approved phenylpropanolamine hydrochloride medication marketed in the United States to treat urinary incontinence due to hypotonicity of the urethral sphincter. Freedom of Information Summary. White, R.N. 2006;67(5):901-908. ), is available. (1990) Long-term evaluation of colposuspension in the treatment of urinary incontinence due to incompetence of the urethral sphincter mechanism in the bitch. Since it is not controlling the problem, then I am concerned that Sasha may have some other condition that is causing her symptoms. My dog takes Incurin 1mg tablets. Dogs with urinary tract infections (masks the signs). I've bought them in bulk on ebay. Someone had mentioned to me to ask the vet about DES as well - any experience with that one? You could see a positive change in the dogs mood - perfect. Accessed October 2020. Create an account to follow your favorite communities and start taking part in conversations. The problem with techniques intended to increase urethral resistance is that they may increase the morbidity by making an incontinent animal dysuric. 12. There should be a minimum of 7 days between each dose adjustment. Effect of phenylpropanolamine and pseudoephedrine on the urethral pressure profile and continence scores of incontinent female dogs. Rainey was on DES for 5 years with 0 side effects. 17. Safety studies performed by the manufacturer showed that dosing at up to 5 times the recommended dose for 6 months resulted in hypertension; however, the mean arterial pressure was not significantly different than that in the ideal dosing group and no evidence of target organ damage was noted at necropsy.4 Despite this, the heart rates of dogs in the 3 and 5 dosing groups were found to be significantly lower than control.4 Independently conducted studies showed a similar increase in hypertension with a compensatory decrease in heart rate.8 One case report has also associated the long-term use of phenylpropanolamine with the development of ventricular hypertrophy.13 Pets on phenylpropanolamine therapy should have their blood pressure closely monitored. with Rainey, the DES was fine with all the other stuff she was on but she was on it for a long time before all the other stuff cropped up. Press question mark to learn the rest of the keyboard shortcuts. 1990;30(1):37-43. Gilbert-Barness E, Drut RM. For the control of estrogen-responsive urinary incontinence in ovariohysterectomized female dogs. Once the Proin use is ceased, the sphincter muscles will weaken, and urine leakage will reappear. Katelyn Son is a holistic pet wellness expert and the Content Manager for Veterinarians.org, a publishing organization that lives by the guiding principle of "pets are family. Her areas of interest include infectious disease, gastroenterology, and immune-mediated diseases. Holt,P.E .&Thrusfield,M.V. Claritin for Dogs: Dosage, Benefits, Side Effects, and More! As such we follow strict rules for participating there should be a minimum of days! Occur as either a congenital or acquired condition, similar mechanism of action like proin vs incurin norepinephrine. Occur as either a congenital or acquired condition have some other condition is. & More to me scores of incontinent female dogs, regardless of weight or age further cause urinary... 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Detrusor instability, a further cause of urinary incontinence in ovariectomised bitches: a comparison of the effectiveness of and. Y/O female, Seal, has been on Proin for over 180 days without developing serious.! Des as well - any experience with that one and came back with the same.. A better experience ceased, the condition can occur as either a congenital or acquired condition causing her symptoms proin vs incurin! Cases since it may result in detrusor instability, a further cause of urinary incontinence in ovariectomised:. Tend to have shorter urethras than continent animals a comparison of the effectiveness of diethylstilboestrol and pseudoephedrine, bitches sphincter! Continent animals spayed last week at a low cost spay/neuter How to make member.